We know that lots of people give their pets Nicotinamide Riboside (NR) (Reviews) hoping to improve their health. But how much should you give them? In response to this very question posted in the comments section at RaisingNAD, the Chromadex (Nicotinamide Riboside “NR” (FAQs)) Scientific & Regulatory Affairs team gave the following advice.

Michael’s Question about his Dog:

“I want to start giving my dogs Tru Niagen but I’m not certain what dose to give them. Not knowing what a reasonable dose to give my dogs would be has held me back from giving them NR and I’m sure other have the same issue. It would be helpful if someone would make a graph with dog or cat weight on one axis and 300 mg equivalent pet dose on the other axis (possibly with other dose equivalents as well).

I have an 8 year old Rottweiler who weighs 100 lbs (45.3 Kg) and an 8 year old Min Pin who weighs 15 lbs (6.8 Kg). I extrapolated the dog equivalent dose from a 300 mg human dose based on information I found online and came up with a 300 mg dose for the 100 lb Rottweiler and a 150 mg dose for the 15 lb Min Pin. Can someone tell me if I did the dose conversion right?

Here are my calculations:

Converted from 60 Kg human with a 1.62 m^2 BSA – Human weight to BSA ratio: 60/1.62 = 37

For the Rottweiler weight to BSA Ratio = 45.3 kg / 1.284 m^2 = 35.3

Rottweiler/Human ratio = 35.3/37 = 0.95

0.95*300 mg = 285 mg — Therefore, a 300 mg dose for the Rottweiler should be fine.

For the Min Pin weight to BSA Ratio = 6.8 kg / 0.363 m^2 = 18.7

Min Pin/Human ratio = 18.7/37 = 0.5

0.5*300 mg = 150 mg

I used this paper for reference:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804402/

And this calculator to get the dog BSA
https://www.vetoncologyconsults.com/bsa-calculator

Response from the Chromadex (NR) Scientific & Regulatory Affairs team:

“There are many published studies on Niagen in various animal models. However, to date, all of these have used very high doses of NR, either to ensure a strong effect is observed or to assess safety. The results of these studies are not directly generalizable to pets.

However, given all the generally positive preclinical and clinical studies conducted on Niagen to date, we would presume there to be a benefit. While at present we don’t have the actual data to make any specific recommendations for pets, the calculations you’ve done appear to be sensible.”

RELATED:

  • FAQs on Feeding Supplement Nicotinamide Riboside (NR) to Pets (Link)
  • Nicotinamide Riboside “NR” (FAQs) (Consumer Reviews)

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