During an ongoing Reddit AMA (Ask Me Anything), NAD+ expert Dr. Charles Brenner (FAQs) was asked about NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) and diabetes. Here’s the Redditor’s question followed by Brenner’s response:

REDDIT Question:

“Do you know of any new studies on NR and prediabetes/diabetes in humans? Does high fat diet cause insulin resistance/diabetes?

DR. CHARLES BRENNER:

“Kinda sorta.

the simplest way to think about diabesity is through energy imbalance.

we live in an environment of lower energy expenditure within a sea of hyperpalatable food that puts us into caloric excess.

people were lean on mostly carb diets for millennia in the far east. for them, adding lots of animal protein and fat is largely responsible for overweight and T2D.

in the west, lots of people blame refined sugars, etc. you can maintain energy balance at high carb or low carb. physics is real

the Dollerup 2018 study was good and bad for the NR field in terms of diabesity.

it showed that 2 grams of NR per day is perfectly safe.

on the other hand, the primary endpoint was deeply unreasonable.

3 months of a vitamin without any dietary or lifestyle intervention is not going to cause weight loss or increased insulin sensitivity.

so the study was a top line failure.

if you look at the paper

https://pubmed.ncbi.nlm.nih.gov/29992272/

in figure 4, we showed that essentially all the men with high fatty liver had a dramatic increase in their liver fat during the course of the study.

unfortunately the study was not randomized for liver.

it needs to be followed up”

Related:

  • Reddit AMA: Dr. Brenner Responds to Qs about Why Take NR (Link)
  • Reddit AMA: Dr. Brenner Responds to Qs about NR & Cancer (Link)
  • Reddit AMA: Dr. Brenner Responds to Qs on NR/NMN Trials (Link)
  • Nicotinamide Riboside “NR” (FAQs) (Life Changing Anecdotes)

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