Although Chromadex announced results of a new study demonstrating a link between NAD decline and alcohol related liver disease earlier today, Dr Charles Brenner (who discovered Nicotinamide Riboside “NR” (FAQs) (Reviews) as an NAD boosting vitamin) has in fact been talking about NAD, alcohol, liver disease, and NR for some time. So has Chromadex CEO Rob Fried. In their own words:

Dr Brenner on the YOU The Owner’s Manual Podcast (May 2020)

“So whether it’s normal aging or many of these disturbances that we encounter as we go through life — overeating….over drinking — attacks the NAD system.

We have human clinical trials that have been completed in healthy populations showing safe oral availability (of NR) and then we have the other ones that have been very short term like 3, 6, and 12 weeks that are looking at older adults, some people with obesity, fatty liver, mild hypertension, and the results are starting to show promise specifically in areas like fatty liver in males, potentially…..”

Dr Brenner on the PRECISIONE: The Healthcast podcast (May 2020)

““I can measure striking attacks on the NAD system in conditions of metabolic stress like sun damage, alcohol, fatty liver, neurodegeneration.

The message coming out (from recent studies) is that it looks as though Nicotinamide Riboside (NR) can potentially improve markers of inflammation in as little as 3 weeks, can improve body composition in women in as little as 6 weeks, and start clearing fatty liver in about 12 weeks in men.”

Dr Brenner on the Conn Jackson podcast (May 2020)

“We found….that the NAD system comes under attack in many conditions of metabolic stress including aging, smoking, overeating, alcohol consumption, heart failure, nerve damage.

We’ve shown that NR is an orally available NAD precursor (booster) vitamin and in animal systems we know that NR has profound activity in preventing and treating conditions of metabolic stress from nerve damage to fatty liver and many others.”

Dr Brenner on WSAW CBS TV 7 (May 2020)

““There are many metabolic stresses that disturb the NAD system. So it’s known that as a function of age NAD levels go down in a number of our important tissues — obesity, Type 2 diabetes, nerve damage, alcohol use, time zone disruption (i.e. jet lag), DNA damage, and reactive oxygen stress disturb the NAD system.”

Dr Brenner on WRAL NBC TV 5 (May 2020)

“Well, NAD levels can be protected with vitamins, essentially.

NAD levels decline in many conditions of metabolic stress.

As I said, obesity, Type 2 diabetes, alcoholism, heart failure.”

Chromadex CEO Rob Fried on the Habits and Hustle Podcast (August 2019)

““The FDA recommended dosage of Tru Niagen is 300mg — candidly, I take much more. I take 600mg a day. But when I’m experiencing any kind of physiological stress — like I was out in the sun OR I traveled across country OR I stayed up late OR I had too many drinks OR I’m fighting something — I help the cells by upping the dose.”

Chromadex CEO Rob Fried on the Optimal Performance Podcast (August 2019)

“You wonder, how come when you’re 20 years old, you get drunk or you party, you come home, you go to sleep and the next day you have the energy to go do it again.

What is the process by which the cells repair themselves so quickly that they’re able to dive right back into such a damaging behavior?

“And the answer is it’s very NAD dependent. The NAD and repair enzymes go to work right away and they’re able to expel the ethanol alcohol out of the cells fairly quickly.

“…From a scientific standpoint, we know that if you take Tru Niagen it will in a very dramatic way elevate blood NAD levels. It will also elevate ATP levels and it will do so very safely without side effects. There’s also some reference to a reduction in blood pressure and an improvement in fatty liver conditions as a result. 

Dr Brenner on the Ben Greenfield Fitness Podcast (July 2018)

“it turns out that our NAD and our NADPH (similar to NAD) is under stress in a number of conditions, like alcohol. So, when we drink (too much) alcohol, our NAD+ is converted to NADH (similar to NAD).  And then the food that we eat when we want it to be converted energy, can be converted to an alcoholic fatty liver.

….most people think, “Oh, I drink alcohol in order to destress.

“But if you talk to a biochemist, a biochemist will tell you, “Oh, alcohol is itself a metabolic stress.”  And it’s a metabolic stress precisely because of what it does to our NAD system.”

Dr Brenner on the BulletProof Radio Podcast (May 2018)

“NAD declines much more sharply in the conditions of metabolic stress that I’ve described with alcohol, overnutrition, noise, sun damage and then these real disease models like nerve degeneration and heart disease.

…Binging (Alcohol), not so good…

…the liver loves taking up Nicotinamide Riboside (NR).

I would say that if you were like going into Passover Seder or some other reason why you’re going to have 4 glasses of wine just as I did on Friday night last week, preparing your body with a little bit more NR is probably a pretty good idea.”

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