Niacin and Nicotinamide Riboside “NR” (FAQs) (Anecdotes) are both forms of Vitamin B3. How are they different?
Category: Niacin
Consumers often wonder whether they can raise their NAD+ levels by simply eating certain foods rich in NAD+ precursors. Unfortunately, NAD+ precursors like Nicotinamide Riboside “NR” (FAQs) (Anecdotes) and Nicotinamide Mononucleotide “NMN” (FAQs and Anecdotes) are only found in trace amounts in food:
As you probably know, there’s a lot of Niacin in Western diets. So, when a new, potentially concerning Niacin study was published last week, the media sounded the alarm, and word spread quickly. Furthermore, those taking NAD+ boosters Nicotinamide Riboside “NR” (FAQs) (Anecdotes) and/or Nicotinamide Mononucleotide “NMN” (FAQs and Anecdotes) began to wonder whether they, too, were at risk. But, as it turns out, there are some serious flaws in this whole narrative.
Those who question the efficacy of NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Life Changing Anecdotes) often point to the work of Princeton’s Dr. Joshua Rabinowitz. Here’s a clip of Dr. Rabinowitz in an appearance on Dr. Peter Attia’s podcast explaining his reasoning followed by a response from NAD+ and NR expert Dr. Charles Brenner:
Earlier today on Twitter, NAD+ and NR expert Dr. Charles Brenner was asked whether Nicotinamide and Nicotinic Acid (Niacin) provide protection against cancer. Here’s what he said:
In late 2019, NAD+ expert Dr. Charles Brenner received a research grant from the Gates Foundation to study the various NAD+ precursors including NMN (FAQs and Anecdotes) and NR (FAQs) (Anecdotes). This past week, Dr. Brenner finally provided a peek at what he found (videos and transcripts below):
Despite skepticism from some NAD experts, NAD IV drip therapy (FAQs) appears to be gaining momentum thanks in large part to podcaster Joe Rogan. But, back in late 2018, FoundMyFitness‘ Dr. Rhonda Patrick said the following on the aforementioned Joe Rogan Experience (we have no evidence that her opinion has changed):
Here’s what Dr. Charles Brenner (who discovered Nicotinamide Riboside “NR” (FAQs) (Reviews) as an NAD precursor vitamin) said in response to a question about boosting NAD with NR vs Niacin on Twitter yesterday:
In a recent pre-clinical study, scientists at the Ho Lab looked at NAD booster Nicotinamide Riboside “NR” (FAQs) (Reviews) and its impact on cancer growth. One key conclusion: “Collectively, these findings reveal that supplementation with NR alleviates mitochondrial dysfunction and further induces additive anti-tumor immunity in conjunction with ICB (immune checkpoint blockade) treatments”. These findings are somewhat consistent with what Dr. Charles Brenner (NAD expert and discoverer of NR as an NAD precursor vitamin) has said about NR and cancer on various platforms over the last year:
A few days ago, Chromadex Chairman Frank Jaksch spoke at the Healthspan Show. In a ~16-minute presentation entitled “Nicotinamide Riboside (NR): The Science of Aging, Cellular Health & NAD+ Precursors”, Jaksch explained NAD boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) in plain English:
If you’re focused on maintaining your NAD levels, you should be aware that simply eating a healthy diet may not be enough. And since your NAD system can also be disturbed by inflammation, aging, and conditions of metabolic stress, there’s a case to be made for supplementation with Nicotinamide Riboside “NR” (FAQs) (Reviews). Dr. Charles Brenner (who discovered NR as an NAD precursor vitamin) made that case in a recent Twitter thread and also explained the abundance of ongoing clinical trials testing NR:
Earlier this week, City of Hope’s Dr. Charles Brenner (who discovered Nicotinamide Riboside “NR” (FAQs) (Reviews) as an NAD boosting vitamin) joined The Genius Life Podcast with Max Lugavere to talk all things NAD and NR. You may recall we covered Dr Rudy Tanzi’s (Harvard professor / Alzheimer’s expert) appearance on the same podcast in mid-November. As usual, Dr Brenner delivered with some actionable comments explained in plain English.
Last week, Dr Charles Brenner — who discovered Nicotinamide Riboside “NR” (FAQs) (Anecdotes) as an NAD boosting vitamin — did a podcast interview where he explained why taking NMN (FAQs and Anecdotes) “makes no sense”. This comment reminded me of a “Tweetorial” Dr Brenner posted on Twitter earlier this year.
In a video podcast interview last week, City of Hope’s Dr. Charles Brenner — who discovered Nicotinamide Riboside “NR” (FAQs) (Reviews) as an NAD boosting vitamin — fielded a host of questions from a New Zealand trained MD. While there’s lots of science here, there’s also lots of accessible information. The following are 4 key takeaways (video interview embedded below).
Educating the public about NAD is a monumental challenge. And it’s obviously key to those companies selling NAD boosters. But thanks to Dr. Rhonda Patrick of FoundMyFitness the concept of NAD is much more accessible. Here she is on the Joe Rogan Podcast:
Dr. Charles Brenner, who discovered Nicotinamide Riboside “NR” (FAQs) (Reviews) as an NAD boosting vitamin and is actively studying NR’s impact on the treatment of COVID-19 recently joined PRECISIONE: The Healthcast podcast to discuss his latest research. Key quotes and podcast embedded below:
Dr. Charles Brenner (FAQs), University of Iowa professor, chief scientific advisor at Chromadex, and discoverer of Nicotinamide Riboside “NR” (FAQs) as an NAD precursor vitamin recently responded to a number of investor questions. Key quotes: