On Dr. Attia’s Podcast, Princeton’s Dr. Rabinowitz Said the Body Barely Sees Vitamin Supplement Nicotinamide Riboside “NR”. Is He Wrong?

Those who question the efficacy of NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Life Changing Anecdotes) often point to the work of Princeton’s Dr. Joshua Rabinowitz. Here’s a clip of Dr. Rabinowitz in an appearance on Dr. Peter Attia’s podcast explaining his reasoning followed by a response from NAD+ and NR expert Dr. Charles Brenner:

Dr. Joshua Rabinowitz with Dr. Peter Attia:

“So, NAD and its precursors are broken down in the gastrointestinal tract.

And, so, if you take NR for example, Nicotinamide Riboside orally, it mainly will enter the body in the form of Nicotinic Acid or Niacin, which is a healthy substance. So there’s nothing wrong with it.

But, except for maybe the epithelium or gastrointestinal tract, the body is not seeing Nicotinamide Riboside (NR)…”

How does Dr. Charles Brenner (who discovered NR as an NAD+ boosting vitamin) respond to Dr. Rabinowitz?

I think a lot of this comes from the very nice Rabinowitz flux analysis paper. In particular figure 7. IV NR still taken up into muscle, but oral NR bioavailability seems very low.

Do you think this might be due to dosage/extraction timing? https://t.co/k8fAhc7ywW

— Keaton minor (@keatonminor) August 1, 2022

like i said, genetics doesn't lie. there are technical issues extracting any tissue & measuring various metabolites

genetics shows that NR is used in skeletal and cardiac muscle

that is a fact

— Charles Brenner, PhD (@CharlesMBrenner) August 1, 2022

disproven genetically

we know that NR acts as NR in skeletal muscle, heart and elsewhere

— Charles Brenner, PhD (@CharlesMBrenner) November 29, 2022

NR is not easily extracted, also blood draws break NR into two pieces

— Charles Brenner, PhD (@CharlesMBrenner) November 29, 2022

What studies show NR is available to skeletal muscle, heart?

If you have some time can you direct me to those studies please

— Hyperodon (@intothewhale) July 18, 2022

https://t.co/n93tARCtwt

— Charles Brenner, PhD (@CharlesMBrenner) July 19, 2022

Related:

• Nicotinamide Riboside “NR” (FAQs) (Life Changing Anecdotes)
• Dr. Charles Brenner (FAQs)

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