Dr. David Sinclair on NMN and Fertility: “You Can Rejuvenate the Female Reproductive System”

We’ve previously heard from a Harvard trained fertility specialist who recommends NAD boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) to patients looking to improve egg quality. We’ve also heard anecdotal evidence from people struggling with fertility that NR might be a treatment solution (“Our Niagen Baby“). Now comes Harvard’s Dr. David Sinclair on a podcast earlier this week claiming he too believes that NAD boosting supplements (in this case, NMN (FAQs and Anecdotes)) may help aspiring parents (video embedded below):

Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52 (12/27/21)

HOST:

“What about estrogen?

Because women are different in the sense that the number of eggs and the ovaries change over time, right?

Do you think that they can maintain estrogen levels over longer periods of time using some of these same protocols?

DR. David Sinclair:

Well, yeah.

I get into trouble from a certain university (he’s employed at Harvard) when I talk about this too much.

HOST:

About estrogen?

DR. David Sinclair:

Just about fertility and — long story.

I don’t want to get too much into the anecdotes.

But I’ll tell you the science…

…which is that if you take a mouse and put it on fasting or caloric restriction up until the point where it should be infertile — so that’s about at a year of age a mouse gets infertile, female mouse..

HOST:

Due to fasting or due to simply to aging?

DR. David Sinclair:

Due to aging.

The fasting — it’s not extreme fast. It’s just less calories.

Then you put them back on a regular food (diet), and they become fertile again for many, many months afterwards.

So the effect on slowing down aging is also on the reproductive system.

I wouldn’t say to any woman — I wouldn’t think that they should become super skinny to try and preserve fertility.

That’s not what I’m saying.

But these pathways that we work on, these sirtuins are known to delay infertility in female animals.

Case in point: I’m one of the lead authors on a paper where we used NMN (FAQs and Anecdotes).

Remember, this is the gas, the fuel, the petrol for the sirtuins.

We gave old mice — one group of mice was 16 months old.

Remember, they became infertile at 12.

Gave them NMN (FAQs and Anecdotes).

And I think it was only six weeks later, they had offspring.

They became fertile again — which goes against biology, the textbook biology which is that female mammals run out of eggs.

Turns out that’s not true.

You can rejuvenate the female reproductive system, and even get them to come out of “mouseopause”, as we call it.

That’s a whole new paradigm in biology as well.

…So what I think is really interesting is that what we’re learning from work that you and your colleagues have done and in my lab as well, is that the body has remarkable powers of healing and recovering from illness and injury.

And what we once thought was a one-way street and you just can’t repair, or you can’t get over these diseases — you CAN reset the system.

And the body can really get rejuvenated in ways that in the future will wonder, why didn’t we work on this earlier?”

Related:

• Nicotinamide Riboside “NR” / “NMN” and Fertility (FAQs)
• NAD+ Boosting Supplement NMN (FAQs and Anecdotes)
• NAD+ Boosting Supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes)

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