On his new podcast series, Dr. David Sinclair claims he’s asked almost daily about NAD+ IVs (FAQs). So what does he think? While he’s impressed with the anecdotal evidence, he’s still waiting for results from human clinical studies:

At the 29:20 mark of the podcast embedded below:

HOST:

“Why don’t we just give NAD directly?

…why don’t we just set up the drip line and get it going?

DR. David Sinclair:

“Well, WE don’t, but others do.

There’s a lot of activity going on in Florida and LA, particularly, of having large drips, long drips of over an hour of NAD.

…they’re done under medical supervision.

But I haven’t yet seen a placebo-controlled trial that would tell us for sure if it’s just wishful thinking or not.

I don’t think so given how many people have been now treated.

And there’s a serious amount of anecdotal data on this — better mood, better energy.

But you know, you cannot conclude anything unless you actually have one of these placebo-controlled trials.

I’d love to be involved if anybody’s going to do one.

I’d love to help.

But I’m asked this probably every day: “NAD IVs, do they work?”

My answer has to be: “we don’t know yet”

HOST:

“What do we think they might be doing?

I mean, what are people trying them for?

DR. David Sinclair:

“Well, they’re used for various things.

It’s been used for many years to treat addiction — whether it’s drug or alcohol.

It’s also used for depression.

And also increasingly for hangovers.

…But the reason that it probably works is there’s an enzyme that detoxifies alcohol called alcohol dehydrogenase.

And a lot of Asians are susceptible to high levels of alcohol because they lack a lot of this enzyme.

Alcohol dehydrogenase needs NAD.

And so what’s probably happening is when you wake up with a hangover, you lack NAD, your liver is depleted.

And if you take NMN (FAQs) or NR (FAQs) you can raise those levels back up, get your liver working again, and get rid of the excess alcohol”

HOST:

“So you think chances are that is actually — it’s not just like a placebo effect?

That there’s a chance that it makes sense that that would work?

DR. David Sinclair:

“I think “makes sense” is the right words to use.

I’m a Harvard professor.

I’m not going to say something works unless I’ve seen hardcore proof.

And I hope that’ll come in the next year or so”

Related:

  • More from DR. Sinclair on NAD+ IVs (Link)
  • What’s the Case for Niagen+ IVs (NR IVs) Over NAD+ IVs? (Link)
  • NAD+ IVs – FAQs (Link)
  • Twitter @RaisingNAD