Will NAD+ Supplement NMN Be Permanently Banned?

Following a recent FDA determination, many consumers are concerned about the future availability of NAD+ boosting supplement NMN (FAQs and Anecdotes). While these concerns appear warranted, Dr. David Sinclair sought to reassure NMN supplement consumers in a Tweetstorm at the end of December (see below):

From Twitter:

On November 4th, 2022, the US Food and Drug Administration (FDA) published a letter regarding the marketing and sales of nicotinamide mononucleotide (NMN) as a supplement to boost NAD levels 1/15
— David Sinclair (@davidasinclair) December 15, 2022

While NAD boosters such as NMN have become popular as supplements, in part because of my research, I am not, and have not, been involved as an owner, cofounder, investor, shareholder, marketer, spokesperson or sponsor of any company that sells NAD boosters as supplements 3/15
— David Sinclair (@davidasinclair) December 15, 2022

The FDA’s letter is based on the Food, Drug & Cosmetic Act, which states “…the term 'dietary supplement' does not include an article authorized for investigation as a new drug…” 5/15
— David Sinclair (@davidasinclair) December 15, 2022

In its action, the FDA is in line with its own regulations, which do not allow for the authorization of a substance to be classified as a dietary supplement if it has already been cleared by the FDA for clinical trials 7/15
— David Sinclair (@davidasinclair) December 15, 2022

…perform clinical trials to address medical conditions like glaucoma, kidney failure, frailty, and rare diseases such as Freidreich’s ataxia 9/15
— David Sinclair (@davidasinclair) December 15, 2022

The important work of bringing NMN to market as an FDA-approved medication is in the best interest of the tens of millions of people who suffer from and will succumb to aging-related diseases 11/15
— David Sinclair (@davidasinclair) December 15, 2022

Whether NMN will remain on the supplement market is not yet known but another molecule, N-acetylcysteine (NAC), which is sold both as a supplement and prescribed as a medicine… 13/15
— David Sinclair (@davidasinclair) December 15, 2022

…for acetaminophen overdosing and as a mucolytic agent in respiratory diseases, fell under the same law and remains on the US supplement market 14/15

Thank you for your patience and please rest assured that advancing the health and well-being of everyone who could potentially benefit from scientific curiosity and discovery will continue to be my highest priority 15/15

Related:

You can read the full Tweetstorm on Twitter HERE.
Dr. Andrew Huberman explains the FDA’s NMN ban to Joe Rogan (Link)
NMN and Dr. David Sinclair (FAQs and Anecdotes)

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Scientific studies & consumer anecdotes about healthier living by reversing NAD+ decline (for information purposes only)

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