Late last year, results of a human clinical study were published supporting the idea that NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Life Changing Anecdotes), upon reaching the brain, can alter the metabolism of certain biological pathways involved in neurodegenerative diseases like Alzheimer’s. For the non-scientist, the following articles (one and two) explain the findings in plain English. For those interested in the science, see the following short video (6 minutes):

Excerpt from the Modern Healthspan video embedded below:

“The paper is important because it uses a novel mechanism to investigate the metabolism of the brain and shows that NR does enter the brain and raises the NAD levels.

Declining NAD levels in the brain contribute to metabolic and cellular dysfunction.

The brain has high energy demands and so is particularly vulnerable to low NAD levels.

NAD precursors have shown efficacy in raising NAD as well as reducing Alzheimer’s markers such as beta amyloid and Tau in animal models.

These precursors such as NR have been shown to be safe and effective at raising NAD levels in humans…”

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