During last week’s Neuro Experience podcast, NAD+ expert Dr. Charles Brenner (FAQs) made the case against NAD+ IVs. Here’s what he said (transcript and video below):

HOST:

“…I do want to get to the bottom of these IVs and how to actually increase levels of NAD.

DR. CHARLES BRENNER:

“…In terms of IV, I don’t really know where they’re getting the IV.

I don’t know how clean that whole system is.

But, all it’s going to do is going to deliver NR.

I’ve heard it’s relatively painful as well.

And, so I think what it is is an inflammatory reaction, because normally NAD is an intracellular metabolite.

So, cells have an innate immune response — just like they have an innate immune response to double-stranded RNA because it’s interpreted as a viral product.

Cells get kind of excited when they see things like extracellular ATP, NAD, intact mitochondria, cell free DNA.

And so that produces an inflammatory reaction.

So, I think it may be painful because it’s producing this inflammatory reaction.

So, I don’t really see a use case for intravenous NAD.

You can basically get the effect from oral NR”

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