You’ve likely heard of NAD+ IVs. What about NR IVs? During an episode of the “Forever Young” podcast last month, Chromadex CEO Rob Fried was asked about future opportunities beyond oral supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes). Here’s what he said:

At the 16:17 mark of the podcast below (transcript following):

“There are people that get this NAD IV treatment – and will swear by it, frankly.

But what happens with people who get an NAD IV treatment is — they’ll get a gram of NAD in an IV.

It could take 3.5, sometimes 4 hours for that full gram to make its way into the body.

And, if you know anyone that’s done it…

Although they love it, because afterward they have an incredible feeling of elation and it’s therapeutic, they sweat, they have nausea.

And these side effects from NAD — and the reason it takes so long, is because NAD can’t get up into the cell.

So, what happens is it breaks down.

And the key thing it breaks down into is what we call niagen or nicotinamide riboside “NR”.

And then it has an elevation.

Now, if you were able to do NR through an IV, you would have significantly higher levels of NAD in the cells, and you could probably get a full gram in maybe half an hour with no side effects.

NR would work via IV or injection in the way NAD would dream of.

Because NR is a nucleoside, it doesn’t have that phosphate problem that both NMN and NAD has.

At the 39:11 mark (transcript following):

“…We know about NAD IV.

And, we know why people have such a hard time with NAD IV.

So, we’re interested in this area for Niagen — of low dose injections or IV drips.

Because it would bypass the gut and bypass the liver.

So, we think that that’s a really exciting area.

But, anything we do, we go through exhaustive research, and FDA approvals, and safety studies.

So, that’s an area of particular interest to us.

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