Rather than deciding between NAD+ boosting supplements NMN (FAQs and Anecdotes) and NR (FAQs) (Anecdotes), some consumers take NAD+. NAD+ expert Dr. Charles Brenner explains why that doesn’t make sense to him (video and transcript below):

Dr. Charles Brenner:

“Well, you could probably find NAD or NADH in a bottle, right?

And what’s going to happen when someone ingests it is it’s going to be degraded down to NR (FAQs) (Anecdotes), basically.

So it’s the phosphate problem again.

NMN (FAQs and Anecdotes) has 1 phosphate — that’s 1 phosphate too many.

NAD has 2 phosphates, and NADP has 3 phosphates.

And in the process of digestion, all of those phosphates come off.

NR is the biggest piece of NAD that can go into cells.

Cells are ready to convert it back up into NAD inside the cells.

But — and the same thing actually goes for intravenous (IVs)…

When people are taking an intravenous NAD (FAQs), the NAD is being degraded down to NR, going into cells as NR.

So it basically doesn’t make biochemical or physiological sense.

It doesn’t bypass any cellular process.

And you don’t know that it’s safe because it doesn’t have a safety dossier behind it”

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