Harvard’s Dr. Rudy Tanzi is a leading expert studying Alzheimer’s disease. He also happens to be a passionate believer in NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Reviews). As a result of his lab work, he’s launching a clinical trial looking at NR in individuals with mild cognitive impairment (MCI) and mild Alzheimer’s dementia (AD) (actual start date March 2, 2022). Here’s why:
Nicotinamide Riboside (NR) and Alzheimer’s:
- Dr. Rudy Tanzi’s Lab Work Suggests B3 Vitamin Nicotinamide Riboside (NR) Could Help Reduce Risk for Alzheimer’s (Link)
- Dr. Tanzi Explains in Great Detail Why He’s Launching a Clinical Trial Testing Nicotinamide Riboside (NR) for Alzheimer’s (Link)
- Dr. Oz’s Mom Has Alzheimers; Her Regimen Includes Nicotinamide Riboside (NR) (Link)
- Dr. Vilhelm Bohr Discussing His Alzheimer’s Research, and the Benefits of Nicotinamide Riboside (NR) (Link)
- WebMD: The End of Alzheimer’s; How New Treatments (e.g. Nicotinamide Riboside “NR”) Might Rewrite The Long Goodbye (Link)
- Dr. Tanzi Convinced the NFL’s New England Patriots to Take a Daily Dose of Nicotinamide Riboside (NR) (Link)
Dr. Tanzi’s Clinical Trial Summary:
“The primary aim of this study is to investigate the effects of exogenously administered nicotinamide riboside (NR) on brain energy metabolism, oxidative stress, and cognitive function in individuals with mild cognitive impairment (MCI) and mild Alzheimer’s dementia (AD).
Mitochondrial function is mediated, in part, by nicotinamide adenine dinucleotide (NAD). Unfortunately, decreases in NAD+ levels are associated with normal aging, and also with numerous diseases such as AD. Accumulating evidence suggests that NR can enhance mitochondrial function and help slow or reverse these age-related abnormalities. Numerous preclinical and clinical studies have been performed using NR and related compounds to boost NAD+ level in human subjects with various diseases or animal models. However, no studies to date have investigated in vivo metabolic and bioenergetic changes (target engagement) associated with NR supplementation. In this project, we aim to investigate the neurobiological mechanisms and clinical effects of NR in patients with MCI and mild AD using in vivo novel neuroimaging techniques.”
Related:
- Dr. Tanzi on the Andy Slavitt podcast (Link)
- Should Consumers Start Taking NR, Especially if They Have Risk Factors for Alzheimer’s? A Scientist (Dr. Martens) Weighs In (Link)
- In an Interview, Scientist (Dr. Martens) Discusses Key Findings from His Alzheimer’s Related Study Using NR (Link)
- Video: First Human Trial Shows NR Can Enter The Brain And Reduces Biomarker For Alzheimer’s (Link)
- What Does Dr. Tanzi Think about the Latest Alzheimer’s Study Including Nicotinamide Riboside “NR”? (Link)
- Nicotinamide Riboside “NR” (FAQs) (Consumer Reviews)
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Lindsay
This sounds huge interesting . My husband was recently diagnosed with mild cognitive / Alzheimer’s so any information would be appreciated