Scientific studies & consumer anecdotes about healthier living by reversing NAD+ decline (for information purposes only)

Author: ezra.marbach Page 1 of 9

The world of NAD+ supplements is confusing. This site is an effort to make sense of it. Please consider sharing it with others. If you have questions or comments, please email me. I respond promptly. Thank you for visiting.

What did we just learn about the Parkinson’s / NR study?

We’ve been waiting patiently for results of a Norwegian human, clinical trial studying NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Reviews). The Niagen folks shared developments on their earnings call last night:

Reddit AMA with Dr. Brenner: IVF docs recommend NR

During last week’s Reddit AMA (“Ask Me Anything”) on the NR SubReddit, NAD+ expert Dr. Charles Brenner (FAQs) was asked about the benefits for new moms taking NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes):

Reddit AMA with Dr. Brenner: “We will be able to demonstrate skin efficacy with oral & topical NR”

During last week’s Reddit AMA (“Ask Me Anything”) on the NR SubReddit, NAD+ expert Dr. Charles Brenner (FAQs) was asked about skin benefits from taking NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes):

“NAD doesn’t work to elevate NAD”

During an investor presentation last week, Niagen CEO Rob Fried said the following:

New animal study suggests Alzheimer’s can be slowed or prevented by raising NAD+ levels

From the Case Western Reserve PR department:

What were results of the Harvard/MGH Long COVID study looking at NR?

We’ve been waiting patiently for results of the Harvard/Mass General Hospital study assessing the efficacy of NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Reviews) in alleviating symptoms associated with “long haul COVID”. Well, the results are finally here.

I’m taking NR. Should I take TMG for methylation?

This is a common question people ask relating to NAD+ boosting supplement Nicotinamide Riboside “NR” (FAQs) (Reviews). What does NAD+ expert Dr. Charles Brenner (FAQs) have to say?

NR clinical trial update

Many are anxiously awaiting results of clinical trials testing NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes). During yesterday’s earnings call, Niagen Bioscience CEO Rob Fried provided the following update:

The NAD molecule can’t enter cells directly

During the presentation portion of yesterdays’s earnings call, Niagen Bioscience CEO Rob Fried said the following:

Why do consumers continue to take NAD+ versus NAD+ boosters?

A recent Fox News article correctly points out that the NAD+ molecule is too large to get into cells:

Podcast: Dr. Charles Brenner makes the case for Nicotinamide Riboside “NR”

In July, NAD+ expert Dr. Charles Brenner (FAQs) was a guest on City of Hope’s “On the Edge of Breakthrough” podcast. He was asked about NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes). Here’s what he said:

There are ongoing studies looking at NR and fertility

During Niagen Bioscience’s recent August earnings call, CEO Rob Fried said the following about the potential to improve fertility chances by supplementing with NAD+ booster Nicotinamide Riboside “NR” (FAQs) (Anecdotes):

Can NAD+ boosters help fight jet lag? NY Magazine weighs in

As we’ve discussed before, NAD+ experts (Drs Sinclair and Brenner) believe that raising NAD+ levels can help you fight jet lag (See here). On a trip to Paris, a New York Magazine reporter put NAD+ booster Nicotinamide Riboside “NR” (FAQs) (Reviews) to the test:

What’s new on the Long COVID study looking at Nicotinamide Riboside (NR)?

From Niagen Bioscience’s (Chromadex) presentation earlier this month at Oppenheimer’s 25th Annual Consumer Growth and E-Commerce Conference:

What’s new on the Parkinson’s study looking at Nicotinamide Riboside (NR)?

From Niagen Bioscience’s (Chromadex) presentation earlier this month at Oppenheimer’s 25th Annual Consumer Growth and E-Commerce Conference:

Top 22 NAD+ Brands on Amazon were lab tested for Potency; One remarkable takeaway

Between August 2024 and April 2025, 22 of the highest selling consumer products labeled as containing NAD+ were purchased from Amazon, and analyzed for NAD+ content by Niagen Bioscience. Here are the results:

What’s new on Nicotinamide Riboside as a possible treatment for Parkinson’s?

From this week’s Niagen Bioscience (formerly Chromadex) earnings conference call:

Nicotinamide Riboside (NR) IV Anecdote #2: “I noticed I was feeling very strong and mentally sharp”

Over the last few years, we’ve heard many anecdotal reports claiming NAD+ IVs provide a variety of significant benefits (Link). What about consumer experiences with the new Nicotinamide Riboside “NR” IVs? Here’s a first person account from Jared Burkholder (originally posted on Facebook; reposting with permission):

Can you measure NAD+ levels?

From the Chromadex earnings call earlier this month:

What’s new on NR as a possible treatment for Parkinson’s?

From the recent Chromadex earnings call:

Why is it harder to get pregnant as you get older? What can you do about it? Dr. Aimee (“the egg whisperer”) explains

In a wide-ranging and ongoing AMA on the NR subreddit, Harvard trained fertility specialist Dr. Aimee (“the egg whisperer”) was asked a question about possible reasons for miscarriages. In her answer, she encourages boosting NAD+ levels with supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes). Here’s the question followed by Dr. Aimee:

What Supplements Does Dr. Aimee (“The Egg Whisperer”) Recommend?

In a wide-ranging and ongoing AMA on the NR subreddit, Harvard trained fertility specialist Dr. Aimee (“the egg whisperer”) was asked what supplements she recommends along with NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes). Here’s what she said:

Is Nicotinamide Riboside Recommended for PCOS Patients?

In a wide-ranging and ongoing AMA on the NR subreddit, Harvard trained fertility specialist Dr. Aimee (“the egg whisperer”) was asked whether she recommends NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) to patients with PCOS (Polycystic Ovary Syndrome). Here’s what she said:

What’s the Optimal Dose of Nicotinamide Riboside for Fertility?

In a wide-ranging and ongoing AMA on the NR subreddit, Harvard trained fertility specialist Dr. Aimee (“the egg whisperer”) was asked what dose of NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) she recommends to patients. Here’s what she said:

Can You Take Nicotinamide Riboside While Pregnant?

In a wide-ranging and ongoing AMA on the NR subreddit, Harvard trained fertility specialist Dr. Aimee (“the egg whisperer”) was asked whether one can continue to take NAD+ boosting supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) while pregnant. Here’s what she said:

Who’s the Biggest Consumer of Nicotinamide Riboside (NR)?

During an appearance earlier this week on the HLTH Forward podcast, Chromadex CEO Rob Fried shared a somewhat surprising fact about consumers of his company’s key product, NAD+ boosting supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes). Here’s what CEO Fried said:

What Were the Top 5 Most Read RaisingNAD.com Posts of 2024?

Since mid-2020, we’ve been working tirelessly to help consumers better understand the complex world of NAD+ and NAD+ boosters like Nicotinamide Riboside “NR” (FAQs) (Anecdotes) and NMN (FAQs and Anecdotes). So, what posts saw the most traffic in 2024?

Key Quotes in Vogue Magazine from Parkinson’s Expert Studying Nicotinamide Riboside “NR”

Many Parkinson’s sufferers are waiting patiently for the expected mid-2025 results of a Norwegian clinical trial studying NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes). The trial’s chief investigator commented on the trial in a mid-December interview with Vogue Magazine:

Can Nicotinamide Riboside Help Combat Fatigue from Cancer Radiation Therapy?

Last week, X/Twitter user BJCohen asked Dr. Charles Brenner (FAQs) whether NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) might help fight fatigue associated with radiation therapy:

Today’s Parent: Could NAD+ Boost Fertility?

We often highlight the work of Dr. Aimee (“the egg whisperer”) who believes that raising NAD+ levels is critical to improving your chances of getting pregnant. She’s quoted often in this article published earlier this week. Aside from hearing more from Dr. Aimee, we bring you this article to share the following quote:

Reddit AMA: A Common Response to Nicotinamide Riboside is Fast Recovery from Scratches and Scrapes

During a recent Reddit AMA (“Ask Me Anything”) on the NR SubReddit, NAD+ expert Dr. Charles Brenner (FAQs) offered some compelling anecdotal information he’s heard from consumers of NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes):

Reddit AMA: Does Nicotinamide Riboside (NR) Deplete other Nutrients By Boosting Body Processes?

During a Reddit AMA (“Ask Me Anything”) last week on the NR SubReddit, NAD+ expert Dr. Charles Brenner (FAQs) was asked whether NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) depletes other nutrients by boosting body processes. See the Redditor’s question, and Dr. Brenner’s response below:

Reddit AMA: Does Most Nicotinamide Riboside (NR) Degrade to Nicotinamide (NAM)?

During a Reddit AMA (“Ask Me Anything”) last week on the NR SubReddit, NAD+ expert Dr. Charles Brenner (FAQs) was asked whether NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) mostly degrades to Nicotinamide (NAM). See Redditor questions, and Dr. Brenner’s answers below:

What are the Key Benefits of Nicotinamide Riboside “NR”?

During an interview last week with Longevity Technology, NAD+ expert Dr. Charles Brenner (FAQs) was asked about the key benefits of taking NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes). Here’s what he said:

Reddit AMA: How Might Nicotinamide Riboside (NR) Impact Your Skin?

During an ongoing Reddit AMA (“Ask Me Anything”) taking place on the NR SubReddit, NAD+ expert Dr. Charles Brenner (FAQs) was asked about possible skin benefits from either taking NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) or applying NR cream to your skin. Here’s what he said:

Reddit AMA: Are Subcutaneous NR Injections More Effective than NR Capsules?

During an ongoing Reddit AMA (“Ask Me Anything”) taking place on the NR subreddit, NAD+ expert Dr. Charles Brenner (FAQs) was asked whether subcutaneous injections (beneath the skin) of Nicotinamide Riboside are more effective than simply taking oral NAD+ boosting vitamin supplements like Nicotinamide Riboside “NR” (FAQs) (Anecdotes). Here’s what he said:

Reddit AMA: What’s the Most Reliable Source of NMN?

During an ongoing Reddit AMA (“Ask Me Anything”) taking place on the NR subreddit, NAD+ expert Dr. Charles Brenner (FAQs) was asked a series of questions about NMN (FAQs and Anecdotes). While we know that his preferred NAD+ booster is vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes), he offered the following for all those looking to make an NMN purchase:

Why Consider a Niagen+ IV (NR IV) Versus Simply Taking Oral Supplement Niagen (NR)?

During last week’s Q3 earnings call, a Wall Street analyst asked Chromadex CEO Rob Fried to compare the bodily impact of the new Niagen+ IV to NAD+ boosting supplement Niagen (Nicotinamide Riboside “NR” (FAQs) (Anecdotes)). Here’s the question followed by CEO Fried’s response:

Why Does Fertility Expert Dr. Aimee (“The Egg Whisperer”) Recommend NR to All of Her Patients Looking to Improve Egg Quality?

As we know, Harvard-trained fertility expert Dr. Aimee (“the egg whisperer”) is a big believer in taking a variety of health supplements to improve egg quality. One of those supplements is NAD+ booster Nicotinamide Riboside “NR” (FAQs)  (Anecdotes). Dr. Aimee made the case for NR on a recent episode of the Pregnantish podcast

Nicotinamide Riboside (NR) IV Anecdote #1: “Honestly I Feel Really Great Today”

Over the last couple of years, we’ve heard a slew of anecdotal reports claiming NAD+ IVs provide a variety of significant benefits (Link). What about consumer experiences with the new Nicotinamide Riboside “NR” (FAQs) (Reviews) IV? Here’s a frank, first person account from Bill Walker (also an oral NR consumer):

What’s the Case for Niagen+ IVs (NR IVs) Over NAD+ IVs?

While we mostly focus here on oral vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Reviews), there’s growing demand for raising NAD levels through NAD+ IVs. And, if you happen to be one of those who enjoy NAD+ IVs, you now have what might be a better alternative: Niagen+ (NR) IVs, which deliver NAD+ booster Nicotinamide Riboside “NR”. Whats the case for Niagen+ (NR) IVs over NAD+ IVs? Below are results of a clinical study comparing Niagen+ (NR) IVs and NAD+ IVs followed by related comments from Chromadex CEO Rob Fried (seller of Niagen+ (NR) IVs) at an August investor conference:

Anecdote #37: “This (NR) has definitely made a difference in my energy levels”

As we await clinical trial results to confirm individual claims about NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Reviews), we’re always interested to see if there are any consistencies in consumer anecdotal reports. Today, we hear from Coach Beede who posted the following earlier today (reposted here with permission):

Anecdote #36: Nicotinamide Riboside (NR) Cleared Mild Psoriasis

In response to yesterday’s Anecdote #35: “I’ve noticed…a dramatic reduction in my psoriasis” (Link), my friend Jeff Gilligan commented that he too enjoyed a similar experience after taking NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Reviews). Here’s what he said:

Anecdote #35: “I’ve Noticed…a Dramatic Reduction in My Psoriasis”

This is not the first time we’ve heard from someone claiming that vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Reviews) helped treat psoriasis. Gary Varvaro told us the same (Link). Some might find these claims plausible considering we’ve also heard from many others reporting remarkable skin benefits after taking NR  (Link). Of course, until we have positive results from human clinical trials, we won’t know whether these claims have any credibility. That said, here is yet another powerful personal experience submitted to us by NR consumer Lawrence Lane:

What Explains the Delay in Releasing Results of the NR / Long COVID Clinical Study?

We all know someone suffering from Long COVID. And, if you’re like me, you’ve been waiting patiently for results of the Harvard/MGH Long COVID clinical study (Details) evaluating NAD+ boosting supplement Nicotinamide Riboside “NR” (FAQs) (Life Changing Anecdotes) as a possible treatment. So, what’s the status of the study? Chromadex CEO Rob Fried explained during an investor presentation at the end of August:

Dr. Oz Takes Nicotiname Riboside “NR”; Asks Wellness Doctor Which Patients Benefits the Most

A few years ago, Dr. Oz shared that his mother was suffering from Alzheimer’s disease. And, at the suggestion of Alzheimer’s expert Dr. Rudy Tanzi, Dr. Oz had his mom taking a variety of vitamins including NAD+ boosting supplement Nicotinamide Riboside “NR” (FAQs) (Life Changing Anecdotes). In late July, Dr. Oz interviewed health and wellness expert Dr. Darshan Shah, asked which patients he prescribes NR to, and who benefits the most. Here’s what he said:

Growing Scientific Evidence Suggesting NR May Help Alzheimer’s Patients

In early August, an article at the Brighter Side discussed a 2022 study suggesting that NAD+ booster Nicotinamide Riboside “NR” (FAQs) (Life Changing Anecdotes) may impact metabolic pathways involved in neurodegenerative diseases like Alzheimer’s. We covered the principal investigator on this study, Dr. Martens, and the results of his study here. So, what studies do we now have demonstrating NR might be helpful for Alzheimer’s patients?

During the Belichick Era, New England Patriots were Taking Nicotinamide Riboside “NR”

During an appearance on the “The Optispan Podcast with Matt Kaeberlein”, NAD+ expert Dr. Charles Brenner (FAQs) said the following about the NFL’s New England Patriots taking vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Reviews):

Dr. Andrew Huberman’s Latest Update on Taking NMN & NR. What Impact Do They Have?

During last week’s Huberman Lab podcast with Dr. Peter Attia, Dr. Andrew Huberman (FAQs) shared his current regimen of NAD+ boosting supplements Nicotinamide Riboside “NR” (FAQs)  (Anecdotes) and NMN (FAQs and Anecdotes). Here’s what he said:

Where Does Dr. Peter Attia See a Possible Signal in Support of NR & NMN Supplementation?

For as long as I can remember, Dr. Peter Attia has been a vocal critic of NAD+ boosting supplements Nicotinamide Riboside “NR” (FAQs)  (Anecdotes) and NMN (FAQs and Anecdotes). But what would change his mind? Here’s what he said on the Huberman Lab podcast last week:

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