Back in 2020, Dr. Charles Brenner (FAQs) joined The Genius Life podcast to discuss NAD+, and vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Reviews). At the time, Brenner addressed specific safety concerns. This week, during a return visit, Brenner offered new comments on a clinical trial he’s particularly interested in:

At the 46:49 mark of the podcast embedded below:

HOST:

“From a high level, for somebody listening to this who’s interested in aging successfully…

If you could make three recommendations for somebody listening to this today that they should start doing if they’re not already, what would those be?

DR. BRENNER:

“I would say challenge yourself would be number one, if not one, two, and three.

So, you want to challenge yourself physically.

You want to keep on trying to do hard things — physically and mentally.

#2 is probably prioritize sleep.

And #3, I think that there is a use case for Nicotinamide Riboside (NR).

When you talk about athletes’ injury recovery and workout recovery — that’s something that is very widely reported with NR.

And one of the things that we want to do is — we want to do a placebo controlled trial of wound repair.

So, quite a lot of people have wiped out on their bike or their skis (Anecdote #1) that are taking Niagen — which is this safety tested Nicotinamide Riboside (NR) — and have recovered just remarkably.

So, the plural of anecdote is not data, right?

But there’s a lot of anecdotes like that where people recovered much more rapidly than they thought.

If you go to the animal literature, you can see these mouse models where NAD is declining in the skin.

And that if you boost their NAD with Nicotinamide Riboside (NR), they heal faster.

From Twitter / X yesterday:

So, we think that this would be a good clinical trial where, for example, everybody that’s getting a shaved biopsy for something that’s not cancer could be given placebo or NR.

And you could test whether skin heals more rapidly with NR.

So, I think that that has a potential to demonstrate something.

For sure, NR demonstrated anti-inflammatory activity in seven trials.

And, inflammation is a component of the kind of decline that occurs in aging that in your liver and your muscle, and all these other tissues, you get different kinds of immune cells that are infiltrating.

Healthy liver is almost all hepatocytes.

And fibrotic or inflamed liver, there’s a lot of immune cells.

And, so, what the effect of NR is is keep the inflammation very low so that multiple organ systems including skeletal muscle and liver can do the things that they’re supposed to do.

HOST:

“And at what dose do you think injury repair and recovery?

DR. BRENNER:

“So, the athletes and clinical trials are typically taking a gram a day.

HOST:

It’s Tru Niagen — it’s like 250 mg per capsule?

DR. BRENNER:

I think the consumer dose is 300 mgs.

But there’s actually a product now that’s a gram.

HOST:

“Wow, because the reason why I’m taking BPC 157 now along with some other peptides, and I recently had a stem cell procedure because I have chronic for a decade now low back pain.

And, so, I’ve tried all the rehab, and the PT, and strengthening my core — all that stuff and it’s been fairly persistent.

So, I’m just trying to throw anything I can at it.

It’s good to know that this might potentially help as well”

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