During this week’s Huberman Lab Podcast, Harvard’s Dr. David Sinclair was asked what to expect from taking NAD+ boosting supplement NMN (FAQs and Anecdotes). Here’s what he said (please consider sharing your own NAD+ supplement experience using the submission form below):

Dr Andrew Huberman:

“Does this protocol for you, does it produce any immediate effects of increased energy, et cetera?

You mentioned that one would, if it’s right for them, would have to take it for at least two weeks to start to see the NAD levels increase?

At that point, when NAD levels increase, could one possibly expect an increase in overall energy, focus, et cetera?

I realize we’re not making promises here.

But I’m just wondering whether or not the only measure of whether or not this protocol is working is whether or not you die at age blank or blank plus 20.

And of course, once you’re dead, you can’t really know if you would’ve lived longer if you’d done something differently and vice versa.

Dr. David Sinclair:

“Sure, well, there was a study, again, by Shin Imai, my good friend at Washington University in St. Louis that showed that improves — remember this insulin sensitivity, which is a good thing.

But you can’t know your insulin sensitivity unless you’re measuring glucose, have a glucose monitor on your arm.

Dr. Huberman:

Do you have one on right now?

Dr. Sinclair:

No, no, I used to, I learned a lot.

Dr. Huberman:

Yeah, last time, I saw you had this thing.

It looks like a small leach — not a large leach.

And it was measuring your blood glucose.

Dr. Sinclair:

They’re very informative because you learn what your body reacts to.

And grapes were really bad — Rhonda Patrick agrees with that.

But the issue was — where were we, Andrew?

Dr. Huberman:

The issue is whether or not you can expect any immediate effects on energy, vitality, focus, just even subjective…

Dr. Sinclair:

So what do you feel, is the question?

And anecdotally, ’cause I’ve been taking this for a long time…

If I don’t take it, I start to feel 50 years old (he’s 52 but claims to feel significantly younger).

It’s horrible.

I can’t think straight.

It may be placebo, but who knows?

But what we’re doing now are very careful clinical trials.

We’ve done the safety for two years.

And we’re now treating elderly patients at Harvard Medical School — with some wonderful colleagues.

And those people are currently in MRIs.

So you can measure the energetics and the NAD levels in their legs as they exercise in real time.

And that will tell us if what we see in the mice is increased endurance actually works.

In the meantime, it’s fun to talk about anecdotes (we agree).

I have a number of athlete friends, some of which have increased their load, their time in marathons, for example.

There’s a good friend of ours in our circle that is winning marathons at age 50 now.

And he attributes that to the protocol that he’s on”

Related:

  • Please consider sharing your own NAD+ supplement experience using the submission form below. Others will undoubtedly benefit.
  • Stanford Neuroscientist Andrew Huberman on His Sister’s Experience Taking NMN (Link)
  • NAD Boosting Supplement NMN (FAQs and Anecdotes)
  • Twitter @RaisingNAD

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