We know that one of the world’s top Alzheimer’s experts recently initiated clinical trials testing vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Reviews) on human patients. But what about Parkinson’s disease? Both Dr David Sinclair and Dr Charles Brenner agree that there’s good reason for clinical trials testing NAD boosters on those suffering from neurodegenerative diseases. So, what’s the latest? Dr. Brenner (NAD expert and discoverer of NR as an NAD precursor vitamin) made the following comment on Twitter earlier this week.
Dr. Charles Brenner on Twitter 2/10/21)
The “sizable clinical trial in Norway” Dr Brenner referred to above was initiated on May 15, 2020 with an estimated enrollment of 400 participants. You can find the details HERE.
The clinical trial appears to be run by the same Norwegian scientist Charalampos Tzoulis, MD, PhD who previously completed a smaller clinical trial using NR on February 10, 2020. Note that as of today, they have yet to report results. See HERE.
Over the years, Dr Brenner has made various comments about NAD, NR, and neurodegenerative diseases like Parkinson’s.
On a 2018 podcast, he said the following:
“in neurodegeneration, NAD is under attack both in peripheral nerves and in central brain injury.
…Central brain injury, NAD goes down…and then you can protect the brain with NR (NAD booster Nicotinamide Riboside).”
That comment was followed by this in 2019:
The fly study, “The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease” was published in 2018 and can be found HERE.
Finally, in 2020, Dr Brenner responded to the following question from @RaisingNAD:
In the Tweet above, Dr Brenner linked to an article titled “Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing“. See HERE.
As for Dr David Sinclair, he said the following in a Summer 2020 Kahn Academy interview:
“…and that makes me think there might be a chance to use these so-called NAD boosting molecules to treat vascular dementia, which is a very pernicious and common disease, actually with not much you can do.
So, I think there’s lot of reason to go and explore NAD boosters in neurodegenerative diseases.
I haven’t done any myself in humans.
I’m aware that there are some studies.
There’s one in Parkinson’s.
There’s one I believe it was also in ALS which I know is not neurodegenerative, central but peripheral.”
Stay tuned.
RELATED:
- What’s the Latest on the Parkinson’s Study Using B3 Vitamin Supplement Nicotinamide Riboside (NR)? (Link)
- Nicotinamide Riboside “NR” for Alzheimer’s (FAQs)
- Nicotinamide Riboside “NR” (FAQs) (Reviews)
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