In July, NAD+ expert Dr. Charles Brenner (FAQs) was a guest on City of Hope’s “On the Edge of Breakthrough” podcast. He was asked about NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes). Here’s what he said:

Dr. Charles Brenner (excerpt at 14:15 mark):

”…A few years later, there was so much interest in NAD that this technology became commercialized.

And it actually produced something called the NAD boosting industry, where there’s like 125 clinical trials of nicotinamide riboside.

There’s other NAD boosting compounds that are being tested in diseases and conditions.

And what do you think of those?

Nicotinamide riboside, there are eight positive clinical trials showing anti-inflammatory activity.

There’s absolutely a use case for nicotinamide riboside.

One of the problems in the field, in the NAD space where they say, you take this and take resveratrol and take some weird other compounds and you won’t age, and it’ll activate your sirtuin genes and this kind of thing.

And so there’s a bunch of stuff that is not evidence-based in the space, but nicotinamide riboside biology is real.

And, you know, there’s a large trial that is being completed in Norway this year in Parkinson’s.

There was a pretty large trial in peripheral artery disease where it was a placebo-controlled trial.

The people with peripheral artery disease on nicotinamide riboside were able to improve their walking speed.

In the placebo group, they decreased their walking speed over the course of the trial because they have a, you know, debilitating illness.

And so there is absolutely use cases for NR, but there’s also, you know, some hype in the NAD space that I tried to tamp down.

I mean, it’s got to be placebo control.”

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