In a wide-ranging and ongoing AMA on the NR subreddit, Harvard trained fertility specialist Dr. Aimee (“the egg whisperer”) was asked whether she recommends NAD+ boosting vitamin supplement Nicotinamide Riboside “NR” (FAQs) (Anecdotes) to patients with PCOS (Polycystic Ovary Syndrome). Here’s what she said:

Question:

“Hello Doc.

I have been taking NR for some weeks, but I understand from your background, that my questions would be better aimed at my wife.

We had a kid 1.5 years ago, and are looking at getting the second one.

She does have fertility issues, so it is going to be through IVF again.

What is actually the impact of NR in fertility issues?

I was completely unaware, so you can point me to some reading if you don’t wish to spend too much time.

She has a combination of PCOS , excess of Lipoprotein A, and antiphospholipid syndrome. And a very low bodyweight on tops.

In any case, she is still “young” (34), so I wasnt thinking of suggesting NR to her, especially since she doesn’t want to “interfere” with the pregnancy planning.

Is it actually something recommendable for her issues? How so?

Dr. Aimee:

“It is.

I recommend NR to all my PCOS patients.

Here are two published studies about this:

https://pubmed.ncbi.nlm.nih.gov/34056649/ (“NAD+ deficiency and mitochondrial dysfunction in granulosa cells of women with polycystic ovary syndrome”)

and

https://www.unboundmedicine.com/medline/citation/39833950/Nicotinamide_riboside_supplementation_ameliorates_ovarian_dysfunction_in_a_PCOS_mouse_model (“Nicotinamide riboside supplementation ameliorates ovarian dysfunction in a PCOS mouse model”)

Related:

  • Consumers, Fertility Specialists (DR. Aimee), and NAD+ Experts discuss taking oral supplement NR to boost fertility chances, egg quality (Link)
  • NAD+ boosting supplement Nicotinamide Riboside “NR” (Consumer Reviews)

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