Until now, conventional wisdom has been that your NAD levels start declining in your 20s and plunge between ages 40 and 60. But in the latest episode of Linda Cooper’s “The New 100 Longevity Campaign”, NAD expert Dr. Charles Brenner appears to have evolved his thinking. As a result, we too might have to evolve our own thinking about when to begin supplementing with NAD boosters like Nicotinamide Riboside “NR” (FAQs) (Reviews).

Conventional Wisdom:

Quotes from Chromadex CEO Rob Fried on a 2019 Podcast:

“We believe that the (NAD) decline begins in your mid-20s.

You’re starting to see a decline in NAD and the processes by which we create NAD also become less effective beginning in your mid-20s.

There are some publications and some researchers that have said that your NAD levels decline in some tissue and in blood as much as 50% by the time you’re 40.

And some have said even as much as another 50% decline from 40 to 60.

So we see a steep decline.”

New Thinking:

Quotes from Dr. Charles Brenner (Discoverer of Nicotinamide Riboside (NR) as an NAD precursor vitamin) in a 2021 interview with The New 100 Longevity Campaign:

“…I list in a Slide that I have in my talks, 9 or 10 conditions of metabolic stress that strikingly disturb the NAD system.

I say that it’s widely reported that NAD declines in aging.

Actually, the data in the 9 or 10 OTHER conditions of metabolic stress are much more striking than aging.

I think that there’s episodes of metabolic stress like sunburn, infection that strikingly attack our NAD system.

Our NAD may sort of slowly decline OR it may be that it’s episodes of infection and inflammation etc that correlates with time.

I’m not sure if it’s time itself — if there’s a timer on our NAD.

I don’t think that that’s really known.”

NOTE:

  • Full interview with Linda Cooper and Dr Brenner can be accessed via the Tweet below.
  • At what age should you consider taking NR? (Link)
  • Nicotinamide Riboside “NR” (FAQs) (Consumer Reviews)
  • Nicotinamide Mononucleotide “NMN” (FAQs)
  • NAD+ IV Drip Therapy (FAQs)

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